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Drosophila melanogaster, in the subgenus Sophophora, was first made famous at the beginning of the 20th century when the Morgan lab at Columbia University confirmed the chromosome theory of inheritance ( Morgan 1910; Bridges 1916 ). Now studied by >1800 labs around the world, D. Melanogaster is a powerful model organism. We compare studies on the effects of neonicotinoids on lethality, reproduction, locomotion, immunity, learning, circadian rhythms and sleep in D. Melanogaster and a range of pollinators. Here, I explored the potential of using Drosophila melanogaster as a model for antimicrobial research, combining methods in Drosophila with microbiology techniques: assessing fly development and feeding, generating germ-free or bacteria-associated Drosophila and in situ microscopy. Abstract Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila melanogaster has proven to be a powerful model for the study of innate immunity. A study on rats and D. Melanogaster found that a moderate HFD with 35 energy percent, compared with an isocaloric control diet without added fat, was unlikely to increase body weight and TAG storage and had a positive effect on lifespan. To determine the fatty acid profile of D. Melanogaster, 725 male and 465 female flies, respectively, were pre-fed in Drosophila bottles with control or HFD under standard conditions for 3 days. After a short starvation period of 1 h, the flies were transferred to a 15 mL tube and weighed with a precision scale (Sartorius, Goettingen, Germany)

 

Abstract Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila melanogaster has proven to be a powerful model for the study of innate immunity. The effects of carbon dioxide anesthesia and anoxia on rapid cold-hardening and chill coma recovery in Drosophila melanogaster. 52 , 1027–1033 (2006). Summary Publications (limited to 20 most recent records) Highly contiguous assemblies of 101 drosophilid genomes. Kim BY, et al. Elife 2021 Jul 19 A Transposon Story: From TE Content to TE Dynamic Invasion of Drosophila Genomes Using the Single-Molecule Sequencing Technology from Oxford Nanopore. Mohamed M, et al. Cells 2020 Jul 25. Is starting to have an important role in chemical genetics, helping to identify the pathways that are affected by current pharmaceuticals, facilitating the design of more efficient derivatives and. Here, we determinate the 48 h, 72 h and 96 h LC 50 values of CIP to Drosophila melanogaster and demonstrate a series of adverse effects after D. Melanogaster was exposed to CIP at a sublethal concentration (3. Treated individuals showed shorter lifespan, delayed development and many of the treated larvae failed to pupate or hatch. Open access Highlights • Alternatives to mammalian testing are needed to detect developmental neurotoxicity • The pesticide chlorpyrifos causes partial lethality and motor dysfunction • Non-lethal levels of BMAA induce motor dysfunction in a dose-dependent manner • Kinematic profiling of adult Drosophila can identify developmental neurotoxicity Clenbuterol cramps potassium

 

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